Mediators of uterine relaxation and contractility in the human non-pregnant uterus
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Mediators of uterine relaxation and contractility in the human non-pregnant uterus

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Published by typescript in [s.l.] .
Written in English


Book details:

Edition Notes

Thesis (Ph.D.) - University of Warwick, 2000.

StatementSevasti I. Zervou.
The Physical Object
Paginationxiv, 234, [17]p.
Number of Pages234
ID Numbers
Open LibraryOL21859571M

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Uterus Relaxation. Uterine relaxation caused by β-mimetic drugs increases the cyclic adenosine monophosphate concentration in the myometrial cell and causes calcium binding to the intracellular sarcoplasmic reticulum. From: Nonhuman Primates in Biomedical Research (Second Edition), Volume 2, Related terms: Uterine Contraction; Anesthesia. Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors. The aim of this study was to assess the uterus-relaxant properties of two thalidomide analogs, methyl 3-(4-nitrophthalimido)(3,4-dimethoxyphenyl)-propanoate (4NO2PDPMe) and methyl 3-(4-aminophthalimido)(3,4 Cited by: 7. Adenosine 3',5'-cyclic monophosphate (cAMP) is believed to be an important mediator of myometrial relaxation, and there is evidence to suggest that guanosine 3',5'-cyclic monophosphate (cGMP) is a. The influence of locally administered Prostaglandin E 2 and F 2α on uterine motility in the intact non-pregnant human uterus. Acta Obstet. Gynecol. Scand., 57, PubMed CrossRef Google Scholar Roth-Brandel, U., Bygdeman, M. and Wiqvist, N. ().

Uterotonic mediators: endothelin-1 (ET-1), arginine vasopressin (AVP), and nitric oxide (NO) play important and well established roles in the regulation of uterine contraction and relaxation [3][4. Despite many studies of animal pregnancy, there is a paucity of knowledge relating to the complex control of human myometrium during pregnancy. It is hypothesized that human myometrium is relatively quiescent during the majority of pregnancy and that as term approaches there is cascade of molecular events that prepare the uterus for labour. Agents used: inhalationed agents, nitrates (IV NTGmcg/ml. With NTG, uterine relaxation should be achievable in 75 to 90 seconds and is maintained for less than 10 minutes (without the need for general anaesthesia), INHALED amyl nitrate, Beta adrenergic agonists (IV ritodrine, IV salbutamol, IV terbutaline) Side Effects: Hypotension (uncommon in euvolaemic patients, treat w/ ephedrine and/or .   Uterine relaxation 1. UTERINE RELAXANTS 2. These are the drugs which decrease uterine motility. USES: Delay or postpone labour. Arrest abortion Dysmenorrhoea Suppression of labour allowed foetus to mature. Premature labour is done only if cervical dilation is.

  Moreover, inhibitors of PDE-4 blocked contractility of pregnant human myometrial tissue in vitro, indicating that PKA likewise modulates uterine relaxation [14,25]. The present study examined the behavioral and uterine-relaxant effects of two compounds, 4NO 2 PDPMe and 4APDPMe, which belong to a family of non-teratogenic thalidomide (Tha. Abstract. The effect of intravenous and intrauterine administration of PGE 1 or PGE 2 and PGF 2α as well as oral administration of PGE 2 on the sensitivity and reactivity of the nonpregnant human uterus was studied. With the use of the flaccid microballoon technique or a micro transducer catheter, uterine recordings were made at frequent intervals throughout the menstrual cycle. The potent excitatory actions of the natural FP‐receptor prostanoid, PGF 2α, and the synthetic analogue, fluprostenol, indicate the presence of FP‐receptors mediating contraction on the human myometrium. 3. PGD 2 produced a biphasic response consisting of excitation followed by relaxation of spontaneous activity of the myometrium. The. Abstract. In the human, prostanoids are known to be important mediators of uterine relaxation and contraction during pregnancy and parturition. We have previously shown that stretch of uterine smooth muscle cells increased prostaglandin H synthase 2 (PGHS-2) mRNA expression, PGHS-2 peptide synthesis and activity, however, the net effect on uterine contractility of this increase in.